When to Train Hypertrophy? Workout Split and Optimal Timing for Muscle Growth
by Ivan Escott
Jan 28, 2025
•5 minutes

Hypertrophy training is a crucial component of any well-rounded fitness regimen, especially for athletes and bodybuilders looking to increase muscle mass. But when is the best time to incorporate hypertrophy training into your workout routine? In this blog post, we'll explore the optimal timing for muscle growth, discuss effective workout splits, and provide insights on how to maximize your hypertrophy training for the best results.
TABLE OF CONTENTS
Understanding Hypertrophy
Hypertrophy in a Training Program
The Hypertrophy Training Day
Choosing Hypertrophy Exercises
Optimal Timing for Muscle Growth
The Bottom Line
Understanding Hypertrophy
Before diving into the timing and programming aspects, let's clarify what hypertrophy means. Simply put, hypertrophy is the growth of muscular mass. There are different types of hypertrophy, such as myofibrillar and sarcoplasmic, which refer to various ways muscles increase in size. While the scientific details are fascinating, our focus will be on practical application for athletes and fitness enthusiasts.

Hypertrophy in a Training Program
In a typical training week, hypertrophy exercises are often programmed as the third exercise of the day. This placement allows for a balanced approach that incorporates other crucial elements of athletic development. The primary purpose of hypertrophy training is to improve structural integrity by building muscle mass around joints, problem areas, and heavily used muscle groups.
Workout Split for Hypertrophy
When it comes to incorporating hypertrophy into your workout split, consider the following structure:
Day 1-4: Focus on other training aspects (e.g., power, strength, speed)
Day 5: Dedicated hypertrophy training day
This five-day split is ideal for athletes training during the off-season. However, if you're limited to four training days per week, you can combine the hypertrophy day with another training focus, such as an impulse day.

The Hypertrophy Training Day
A typical hypertrophy training day should be structured as follows:
Start with a technical coordination movement (e.g., linebacker push press or Pennsylvania press)
Follow with an absolute strength movement (e.g., close-grip bench press with higher reps)
Pair hypertrophic movements with accessory exercises
This structure allows for a comprehensive approach to muscle growth while maintaining other important aspects of athletic development.
Choosing Hypertrophy Exercises
When selecting exercises for hypertrophy training, think of it as adding spices to a recipe. You can choose from both compound and isolation movements, depending on your goals and needs. Some examples include:
Compound movements:

Walking lunges
Dumbbell bench presses
Lat pulldowns
Single-leg squats
Goblet squats
Dumbbell deadlifts
Single-leg RDLs
Isolation movements:

Preacher curls
Tricep pushdowns
Leg curls
Leg extensions
Calf raises
Remember, this is not an exhaustive list. Feel free to expand your "hypertrophic spice rack" with exercises that target your specific needs and goals.
Benefits of Hypertrophy Training
Improved Structural Integrity: Hypertrophy exercises help address past injuries and strengthen areas that may have atrophied or have activation issues.
Enhanced Healing: The increased blood flow from hypertrophy training can aid in nutrient delivery and promote healing in targeted areas.
Joint Stability: Hypertrophy exercises increase joint stability by creating tendon and ligament hypertrophy, reducing the likelihood of injury.
Neural Drive Development: For beginner athletes, hypertrophy training is the quickest way to improve coordination by developing neural drive.
Strength Gains: Larger muscle fibers resulting from hypertrophy can create greater power output, translating to improved sports performance.
Mental Toughness: Supersetting or tri-setting hypertrophy and accessory movements can improve athletes' mindsets and ability to handle stress.
Optimal Timing for Muscle Growth
To maximize muscle growth, consider the following guidelines for sets, reps, and rest periods:
Sets: Aim for 4-5 sets per exercise, with the potential to increase to 6-10 sets for more advanced athletes or during specific training phases.
Reps: For hypertrophy and accessory movements, use higher rep ranges (10-17 reps) to target muscle growth and improve structural integrity. For absolute strength movements, vary the rep range based on the training phase and athlete's experience level.
Rest Periods: Manipulate rest times to achieve different goals. For example: Use "on the minute" (OTM) rest periods to develop power endurance; Implement cluster sets for absolute strength movements to accumulate volume with minimal recovery time; Adjust rest periods in contrast methods to focus on power or power endurance, depending on the athlete's needs
Progressive Overload and Periodization
To ensure continuous muscle growth, incorporate progressive overload and periodization into your hypertrophy training. Here's a sample progression through different training phases:
Exposure Phase:
- Technical coordination: 5-7 sets of 3-4 reps
- Absolute strength: 4-5 sets of 5-7 reps
- Hypertrophy: 4-5 sets of 10-17 reps
Comprehension Phase:
- Technical coordination: 5-7 sets of 2-4 reps
- Absolute strength: 4-5 sets of 5-7 reps (with drop sets of 10+ reps)
- Hypertrophy: 4-5 sets of 10-17 reps
Ascension Phase:
- Technical coordination: 5-7 sets of 1-3 reps
- Absolute strength: 4-5 sets of 3-5 reps
- Hypertrophy: 4-5 sets of 5-9 reps (focusing on myofibrillar hypertrophy)
Summit Phase:
- Technical coordination: 7-10 sets of 1-2 reps
- Absolute strength: 5-6 sets of 2-4 reps
- Hypertrophy: 4-5 sets of 5-9 reps (continuing myofibrillar focus)
Realization Phase:
- Technical coordination: 3 sets of 2 reps
- Absolute strength: 3 sets of 2-4 reps
- Hypertrophy: 2-3 sets of 5-7 reps
The Bottom Line
Incorporating hypertrophy training into your workout routine is essential for muscle growth, improved structural integrity, and enhanced athletic performance. By understanding the optimal timing, exercise selection, and programming variables, you can maximize your results and achieve your muscle-building goals.
Remember to tailor your hypertrophy training to your specific needs, experience level, and overall training program. As you progress through different training phases, adjust your approach to ensure continued growth and development. With consistency and proper programming, you'll be well on your way to building the muscular physique and athletic performance you desire.
Ivan Escott
Ivan is a national-level Olympic weightlifter and performance coach at Garage Strength Sports Performance.